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KMID : 0829220140380050273
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Korean Journal of Oral and Maxillofacial Pathology
2014 Volume.38 No. 5 p.273 ~ p.280
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Differential Expression of Lysyl Oxidase in Mucoepidermoid Carcinoma, Adenoid Cystic Carcinoma and Pleomorphic Adenoma
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강경림:Kang Kyung-Rim
최소영:Choi So-Young/윤혜정:Yoon Hye-Jung/홍성두:Hong Seong-Doo/홍성두:Hong Seong-Doo/이재일:Lee Jae-Il/홍삼표:Hong Sam-Pyo
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Abstract
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Lysyl oxidase (LOX) family, the copper dependent amine oxidase, oxidizes lysine residues in extracellular collagen and elastin. LOX increases the strength of the extracellular matrix and plays an important role in tumor development and metastasis. It has been reported that increased LOX protein and RNA are found in head and neck squamous cell carcinoma. Moreover some studies regarded LOX as a prognostic marker of oral and oropharyngeal squamous cell carcinoma. However there has not been any report on LOX expression of salivary gland tumors. Here, we investigated LOX expression in mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) of salivary gland and compare it to those of pleomorphic adenoma (PA). We evaluated LOX expression in eighteen MEC, eighteen ACC and twenty PA cases by immunohistochemical examination. Whereas PA showed relatively low density of LOX expression, ACC revealed more cases that showing high staining intensities for LOX. Significantly increased LOX expression was found in the cases of ACC when compared to those of PA (P = 0.010).
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KEYWORD
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Lysyl oxidase, Mucoepidermoid carcinoma, Adenoid cystic carcinoma, Pleomorphic adenoma
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